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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PURA

contributors: mct - updated : 28-09-2013

HGNC name	purine-rich element binding protein A
HGNC id	9701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL5Q31.3 , MRD31

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in myelodysplastic syndrome, acute myelogenous leukemia constitutional         leads to a prolongation of neuronal precursor cell proliferation during postnatal development, a reduced expression of MAP2 and pathological hyperphosphorylation of axonal proteins

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate for hormone-refractory prostate cancer

ANIMAL & CELL MODELS

	PURA(-/-) mice
	Pur&
	945;(-/-) mice displayed a megalencephaly and histopathological findings including axonal swellings and hyperphosphorylation of neurofilaments