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FLASH GENE
Symbol PURA contributors: mct - updated : 28-09-2013
HGNC name purine-rich element binding protein A
HGNC id 9701
ASSOCIATED DISORDERS
corresponding disease(s) DEL5Q31.3 , MRD31
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in myelodysplastic syndrome, acute myelogenous leukemia
constitutional        
leads to a prolongation of neuronal precursor cell proliferation during postnatal development, a reduced expression of MAP2 and pathological hyperphosphorylation of axonal proteins
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveprostate
for hormone-refractory prostate cancer
ANIMAL & CELL MODELS
  • PURA(-/-) mice
  • Pur&
  • 945;(-/-) mice displayed a megalencephaly and histopathological findings including axonal swellings and hyperphosphorylation of neurofilaments