Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PURA

contributors: mct - updated : 28-09-2013

HGNC name	purine-rich element binding protein A
HGNC id	9701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005859 1 - 5304 NP_005850 34.8 322 - 2003 12972605

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Reproductive female system ovary         male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal glycine-rich region
	three repeats of a 23-amino acid class I motif
	two repeats of a 26-amino acid class II motif
	an amphipathic helix
	a C-terminal glutamine-glutamate-rich domain

conjugated

PhosphoP

mono polymer

homomer , heteromer , dimer , trimer

HOMOLOGY

interspecies	homolog to murine Pura (99.7 pc)
	homolog to rattus Pura (99.7 pc)

intraspecies

homolog to PURB

Homologene

FAMILY

PUR DNA-binding protein family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus
text	associated with polyribosomes

basic FUNCTION	may be play a role in the initiation of DNA replication and in recombination
	involved in targeting mRNPs to polyribosomes in cooperation with other RNA-binding proteins
	acting as a probable transcription activator
	PURalpha and PURbeta repressed alpha-myosin heavy chain (alpha-MHC) gene expression in the presence of upstream regulatory sequences of the gene
	participate in transcriptional as well as translational regulation of alpha-MHC expression in cardiac myocytes
	PURA, and PURB, collaborate with Sp3 to regulate a transcriptional program that enables muscle cells to remodel their phenotype
	structurally related single-stranded DNA/RNA-binding proteins implicated in the control of cell growth and differentiation
	Pur alpha and Pur beta repress smooth muscle alpha-actin gene transcription by means of DNA strand-selective cis-element binding and cell type-dependent protein-protein interactions
	involved in many aspects of nucleic acid homeostasis including the regulation of DNA replication, DNA repair, gene transcription, RNA transport, and mRNA translation
	has a role in nucleotide excision repair and the repair of UVC-induced DNA damage
	plays an important role in a variety of cellular processes including transcriptional regulation, cell proliferation and oncogenic transformation
	potential role in the regulation of the expression and cellular distribution of dendritic and axonal protein
	importance in the proliferation of neuronal precursor cells during postnatal brain development, suggesting a role in the regulation of the expression and cellular distribution of dendritic and axonal proteins
	DNA-binding protein with high affinity for the single-stranded PUR-motif (GGN)n
	critical for myeloid cell development, muscle development, and brain development, including trafficking of mRNA to neuronal dendrites

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, replication
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	nervous system development
	positive regulation of cell proliferation

PATHWAY

metabolism

signaling

a component	heterodimer with PURB
	heterotrimer with PURB and YBX1/Y-box protein 1

INTERACTION

DNA	specifically binding to the purine-rich single strand of the PUR element located upstream of the MYC gene

RNA

small molecule

protein	interacting with CDK2
	binding to E2F1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL5Q31.3 , MRD31

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in myelodysplastic syndrome, acute myelogenous leukemia constitutional         leads to a prolongation of neuronal precursor cell proliferation during postnatal development, a reduced expression of MAP2 and pathological hyperphosphorylation of axonal proteins

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate for hormone-refractory prostate cancer

ANIMAL & CELL MODELS

	PURA(-/-) mice
	Pur&
	945;(-/-) mice displayed a megalencephaly and histopathological findings including axonal swellings and hyperphosphorylation of neurofilaments