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FLASH GENE

Symbol

ID4

contributors: SGE - updated : 06-09-2015

HGNC name	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
HGNC id	5363

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         by promoter hypermethylation in acute myeloid leukemia tumoral     --other   dysregulated in breast and ovarian carcinomas with BRCA1 tumoral     --low   in breast cancer by aberrant hypermethylation of the promoter region, increasing risk of lymph node metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ID4 could be efficacious for identifying previously unrecognized human spermatogonial subpopulations in conjunction with other putative human stem cell markers
Therapy target	ID4 methylation could serve as a prognostic biomarker in breast cancer (Noetzel 2008)
	may be a therapeutic target in myelodysplastic syndrome (MDS) (Wang 2010)

ANIMAL & CELL MODELS