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FLASH GENE
Symbol ID4 contributors: SGE - updated : 06-09-2010
HGNC name inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
HGNC id 5363
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
by promoter hypermethylation in acute myeloid leukemia
tumoral     --other  
dysregulated in breast and ovarian carcinomas with BRCA1
tumoral     --low  
in breast cancer by aberrant hypermethylation of the promoter region, increasing risk of lymph node metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • ID4 methylation could serve as a prognostic biomarker in breast cancer (Noetzel 2008)
  • may be a therapeutic target in myelodysplastic syndrome (MDS) (Wang 2010)
  • ANIMAL & CELL MODELS