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FLASH GENE

Symbol

FABP3

contributors: mct - updated : 17-08-2011

HGNC name	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
HGNC id	3557

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   aberrant expression may alter membrane fluidity and signal transduction, and consequently could be involved in cellular dysfunction in neurodegenerative disorders

Susceptibility

to essential hypertension (EH)

Variant & Polymorphism SNP	G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects

Candidate gene
Marker	useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid
Therapy target
	System Type Disorder Pubmed obesity     potential target for modulation of energy dissipation

ANIMAL & CELL MODELS

Fabp3(-/-) mice exhibit extreme cold sensitivity despite induction of uncoupling and oxidative genes and hydrolysis of brown adipose tissue lipid store