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FLASH GENE
Symbol FABP3 contributors: mct - updated : 17-08-2011
HGNC name fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
HGNC id 3557
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
repeated structure + topology beta barrel and remarkable structural signature
HOMOLOGY
interspecies homolog to murine Fabp3
Homologene
FAMILY lipocalin/calycins family (FABP/CRBP family of transporters)
CATEGORY tumor suppressor , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text
  • localized in inner and outer pillar cells and outer phalangeal cells
    • basic FUNCTION
  • fatty acid binding protein, tumor suppressor for breast cancer
  • participating in the uptake, intracellular metabolism and/or transport of long-chain fatty acids
  • support potentially fat accumulation in the hypoxic placenta
  • play important roles in the regulation of the hearing function
  • heart-type fatty acid-binding protein, essential for cold tolerance and efficient fatty acid oxidation, in brown adipose tissue
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel interacting partner for integrin alpha-subunits, and its expression modulates integrin activity and suppresses cell invasion in breast cancer patients
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrant expression may alter membrane fluidity and signal transduction, and consequently could be involved in cellular dysfunction in neurodegenerative disorders
    Susceptibility to essential hypertension (EH)
    Variant & Polymorphism SNP
  • G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects
    • Candidate gene
    Marker
  • useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid
    • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential target for modulation of energy dissipation
    ANIMAL & CELL MODELS
  • Fabp3(-/-) mice exhibit extreme cold sensitivity despite induction of uncoupling and oxidative genes and hydrolysis of brown adipose tissue lipid store