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FLASH GENE

Symbol

FABP3

contributors: mct - updated : 17-08-2011

HGNC name	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
HGNC id	3557

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p35.2      Physical location : 31.838.099 - 31.845.923
Synonym name	mammary derived growth inhibitor
Synonym symbol(s)	MDGI, HFABP, FABP11, H-FABP, O-FABP

DNA

TYPE	functioning gene
STRUCTURE	7.82 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004102 4 - 1097 - 133 - 2010 20802519

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Hearing/Equilibrium ear inner cochlea     Homo sapiens Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

repeated structure + topology beta barrel and remarkable structural signature

HOMOLOGY

interspecies

homolog to murine Fabp3

Homologene

FAMILY

lipocalin/calycins family (FABP/CRBP family of transporters)

CATEGORY

tumor suppressor , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	localized in inner and outer pillar cells and outer phalangeal cells

basic FUNCTION	fatty acid binding protein, tumor suppressor for breast cancer
	participating in the uptake, intracellular metabolism and/or transport of long-chain fatty acids
	support potentially fat accumulation in the hypoxic placenta
	play important roles in the regulation of the hearing function
	heart-type fatty acid-binding protein, essential for cold tolerance and efficient fatty acid oxidation, in brown adipose tissue

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

novel interacting partner for integrin alpha-subunits, and its expression modulates integrin activity and suppresses cell invasion in breast cancer patients

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   aberrant expression may alter membrane fluidity and signal transduction, and consequently could be involved in cellular dysfunction in neurodegenerative disorders

Susceptibility

to essential hypertension (EH)

Variant & Polymorphism SNP	G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects

Candidate gene
Marker	useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid
Therapy target
	System Type Disorder Pubmed obesity     potential target for modulation of energy dissipation

ANIMAL & CELL MODELS

Fabp3(-/-) mice exhibit extreme cold sensitivity despite induction of uncoupling and oxidative genes and hydrolysis of brown adipose tissue lipid store