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FLASH GENE
Symbol MSH3 contributors: mct - updated : 14-09-2016
HGNC name mutS homolog 3 (E. coli)
HGNC id 7326
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region of homology with other Muts or MutL homologs, comprising a region of 150 aminoacids encompassing a putative helix-turn-helix domain associated with an adenine nucleotide and magnesium binding site
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast mutator gene
    homolog to C.elegans C14C10.4
    Homologene
    FAMILY
  • DNA mismatch repair mutS family
  • MSH3 subfamily
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • protein possessing an intrinsic low-level ATPase activity
  • MSH2/MSH3, discriminates between a repair-competent and a repair-resistant loop by sensing the conformational dynamics of their junctions
  • MSH2-MSH3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions
  • MSH2-MSH3 is required for 3prime non-homologous tail removal in double-strand break repair and, MSH2-MSH3 binds double-strand/single-strand junctions and initiates repair in an ATP-dependent manner
  • MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in TP53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as well
  • MSH2-MSH3 plays an important role in shifting the expansion-contraction equilibrium toward expansion in the early stages of Trinucleotide repeat (TNR) tract expansion
    • CELLULAR PROCESS nucleotide, repair, mismatch repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with MSH2 in mismatch repair
  • MSH2-MSH3 heterodimer recognizes various DNA mispairs, including loops of DNA ranging from 1 to 14 nucleotides and some base-base mispairs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSH6 to tumor supression
  • MLH1
  • MLH1-MLH3, a meiotic crossover and DNA mismatch repair factor, is a MSH2-MSH3-stimulated endonuclease
  • MSH2 interacts with MSH6 or MSH3 to form the MutSalpha or MutSbeta complex, respectively, which recognize base-base mispairs and insertions/deletions and initiate the repair process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FAP4
    Susceptibility to prostate cancer
    Variant & Polymorphism other
  • association of MSH3 gene polymorphisms in prostate cancer
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Msh3 knock out mouse