Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MSH3

contributors: mct - updated : 14-09-2016

HGNC name	mutS homolog 3 (E. coli)
HGNC id	7326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002439 24 polyA site 4645 NP_002430 - 1137 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial barrier/lining       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a region of homology with other Muts or MutL homologs, comprising a region of 150 aminoacids encompassing a putative helix-turn-helix domain associated with an adenine nucleotide and magnesium binding site

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to yeast mutator gene
	homolog to C.elegans C14C10.4

Homologene

FAMILY	DNA mismatch repair mutS family
	MSH3 subfamily

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	protein possessing an intrinsic low-level ATPase activity
	MSH2/MSH3, discriminates between a repair-competent and a repair-resistant loop by sensing the conformational dynamics of their junctions
	MSH2-MSH3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions
	MSH2-MSH3 is required for 3prime non-homologous tail removal in double-strand break repair and, MSH2-MSH3 binds double-strand/single-strand junctions and initiates repair in an ATP-dependent manner
	MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in TP53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as well
	MSH2-MSH3 plays an important role in shifting the expansion-contraction equilibrium toward expansion in the early stages of Trinucleotide repeat (TNR) tract expansion

CELLULAR PROCESS	nucleotide, repair, mismatch repair
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complexing with MSH2 in mismatch repair
	MSH2-MSH3 heterodimer recognizes various DNA mispairs, including loops of DNA ranging from 1 to 14 nucleotides and some base-base mispairs

INTERACTION

DNA

RNA

small molecule

protein	MSH6 to tumor supression
	MLH1
	MLH1-MLH3, a meiotic crossover and DNA mismatch repair factor, is a MSH2-MSH3-stimulated endonuclease
	MSH2 interacts with MSH6 or MSH3 to form the MutSalpha or MutSbeta complex, respectively, which recognize base-base mispairs and insertions/deletions and initiate the repair process

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FAP4

Susceptibility

to prostate cancer

Variant & Polymorphism other	association of MSH3 gene polymorphisms in prostate cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Msh3 knock out mouse