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FLASH GENE

Symbol

CDK7

contributors: mct - updated : 18-05-2013

HGNC name	cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
HGNC id	1778

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	42.64 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D5S823 - CCNB1 - CDK7 - OCLN - BIRC1 - SMN2 - SERF2 - qter
Authors	Growney (00)
Text	see SMA

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001799 12 - 1534 - 346 - 1999 10224071

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart

cell lineage
cell lines	breast cancer lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to Xenopus p40-M015
	homolog to murine Cdk7
	ortholog to yeast S.cerevisiae cdc28

Homologene

FAMILY	cyclin-dependent kinase family
	ser/thr family of protein kinases

CATEGORY

enzyme , regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm

basic FUNCTION	CDK-activating kinase 1, linking transcription and the cell-cyle machinery
	functions as a master cell cycle regulator by phosphorylating cyclin-dependent kinases for cell cycle progression
	having a putative role in oxidative stress
	submodule of TFIIH acting as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity
	ELL and CDK7 play essential yet distinct roles during transcription-coupled repair (TCR)

CELLULAR PROCESS	cell cycle, progression
	cell life, proliferation/growth
	nucleotide, repair
	nucleotide, transcription, initiation

PHYSIOLOGICAL PROCESS

text	cell cycle control

PATHWAY

metabolism

signaling

a component	component of the multisubunit complex TFIIH (GTF2H)
	component of an aternary complex with CCNH and MNAT1 (see symbols)
	trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH )

INTERACTION

DNA

RNA

small molecule

protein	activating POLR2A, when complexed and associated with GTF2H
	phosphorylating CDK2 and CDC2
	PRKCI associates with CDK7
	CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation

cell & other

REGULATION

inhibited by

inactivated by phosphorylation

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to breast cancer

Variant & Polymorphism other	CDK7 TT genotype had increased risk of breast cancer (

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS