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FLASH GENE
Symbol SLC26A2 contributors: mct/npt - updated : 28-02-2014
HGNC name solute carrier family 26 (sulfate transporter), member 2
HGNC id 10994
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N- and C-cytoplasmic termini
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail with a sulfate transporter motif
  • a relatively hydrophobic region near the C terminus, the STAS domain (sulfate transporter and anti-sigma factor antagonist)
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Slc26a2 (81.1 pc)
    homolog to murine Slc26a2 (80.9 pc)
    Homologene
    FAMILY
  • anion exchanger family
  • SLC26A/SULP transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in proteoglycan sulfate activation
  • may play a role in endochondral bone formation
  • functions as an electroneutral SO42&
    • 8722;/OH&
    8722;(H+)/Cl&
    8722; exchanger
  • physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport
  • multiple roles in chondrocyte biology and importance of SLC26A2-mediated protein sulfation in cell signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+ independent sulfate transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation of SLC26A2 by an extracellular anion binding site
    ASSOCIATED DISORDERS
    corresponding disease(s) ACG1B , ATSG2 , DTD , EDM4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nephrolithiasis in the Slc26a6(-/-) mouse is accompanied by 50-75p100 reduction in intestinal oxalate secretion with unchanged intestinal oxalate absorption
  • collagen fibrils in bone were thinner and less organized in dtd compared to wild-type mice, suggesting that the low bone mass observed in mutant mice could possibly be linked to the different bone matrix compositions/organizations in dtd mice triggering changes in osteoblast and osteoclast activities