| basic FUNCTION
| important switch factor directing Ig-E synthesis |
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acting as an immunoregulatory and effector cytokine in allergic diseases such as bronchial asthma |
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synergizing with IL2 in regulating interferon-gamma synthesis |
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may be critical in regulating inflammatory and immune responses |
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involved in several stages of B-cell maturation and differentiation |
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up-regulating CD23 and MHC class II expression |
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promoting IgE isotype switching of B cells |
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down-regulating macrophage activity |
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inhibiting the production of pro-inflammatory cytokines and chemokines |
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triggers microglial NADPH oxidase-derived oxidative stress, leading to the degeneration of hippocampal neurons, as occurs in cases of Alzheimer disease  |
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inhibition of matrix metalloproteinas-3 (MMP-3) synthetis in fibroblasts |
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induce the death of activated microglia |
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involved in excessive deposition of extracellular matrix (EMC) proteins in giant papillae |
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IL10 and IL13 play important roles in Th2 cell differentiation and production of autoantibodies in patients with (SLE) |
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central role for the IL13/IL13RA1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of CFTR, suggesting an important role for this pathway in secretory diarrhea |
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induces phosphorylation of Src Tyrosine Kinase in primary monocytes |
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induces HCK tyrosine phosphorylation in alternatively activated monocytes/macrophages, suggesting that HCK may be involved in IL13 signal transduction in monocytes |
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IL4 and IL13 prime the migrational response of haemopoietic progenitor cells to CXCL12 by enhancing the incorporation of CXCR4 into lipid rafts |
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central mediator of airway hyperresponsiveness and mucus expression, both hallmarks of asthma |
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IL13 and IL4R may play an important role in the etiology of renal cell carcinoma |
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IL13 and IL4 can uniquely affect the expression of particular genes such as DUSP1 and TIMP33 and do so through different Jaks |
