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FLASH GENE
Symbol GLRA1 contributors: mct - updated : 24-05-2011
HGNC name glycine receptor, alpha 1
HGNC id 4326
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand gated ion (Cl) channel
  • four transmembrane segments (4TM)
  • a ligand-binding extracellular domain (ECD)
  • multifunctional basic motif of the TM3-4 loop is capable of mediating a karyopherin-dependent intracellular sorting of GLRA1 (
    • mono polymer homomer , heteromer , pentamer
    HOMOLOGY
    Homologene
    FAMILY
  • ligand-gated chloride channel family
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • glycine fast reponse transduction, inhibitory chloride channel
  • ligand-gated ion channel that mediates fast synaptic inhibition in the vertebrate central nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • three ligand-binding alpha1 subunits and two structural beta subunits
    • INTERACTION
    DNA
    RNA
    small molecule other,
  • strychnine
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) STHE1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS