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FLASH GENE
Symbol GLRA1 contributors: mct - updated : 24-05-2011
HGNC name glycine receptor, alpha 1
HGNC id 4326
RNA
TRANSCRIPTS type messenger
text two forms differing by exon 5, 5a or 5b
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1811 - 449 - 2010 19959465
- - 1835 - 457 - 2010 19959465
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrain   
 spinal cord    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand gated ion (Cl) channel
  • four transmembrane segments (4TM)
  • a ligand-binding extracellular domain (ECD)
  • multifunctional basic motif of the TM3-4 loop is capable of mediating a karyopherin-dependent intracellular sorting of GLRA1 (
  • mono polymer homomer , heteromer , pentamer
    HOMOLOGY
    Homologene
    FAMILY
  • ligand-gated chloride channel family
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • glycine fast reponse transduction, inhibitory chloride channel
  • ligand-gated ion channel that mediates fast synaptic inhibition in the vertebrate central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • three ligand-binding alpha1 subunits and two structural beta subunits
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • strychnine
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) STHE1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS