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FLASH GENE
Symbol HBEGF contributors: mct - updated : 28-04-2016
HGNC name heparin-binding EGF-like growth factor
HGNC id 3059
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one EGF-like domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Hbegf
    ortholog to rattus dtr
    Homologene
    FAMILY
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in macrophage-mediated cellular proliferation
  • mitogenic for fibroblasts and smooth muscle but not endothelial cells
  • with PTGS2 and ST6GALNAC5, are mediators of cancer cell passage through the blood-brain barrier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EGR4 (mediates EGFR signaling pathway through HBEGF)
  • HAS3 is induced by HBEGF and seems mainly involved in atopic dermatitis (AD) epidermis
  • SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in preeclampsia and in fetal growth retardation
    constitutional     --low  
    in smooth muscle or endothelial cell lineages causes heart malformation
    tumoral     --over  
    in ovarian, gastric, and breast cancer, melanoma and glioblastoma cells
    Susceptibility to dyphteria toxin
    Variant & Polymorphism
    Candidate gene marker of the keratinocyte's response to a challenging environment and this growth factor alters the phenotype of keratinocytes in a manner similar to that observed during epidermal repair
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    cancer therapy
    ANIMAL & CELL MODELS