Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PPP2CA

contributors: mct/npt/pgu - updated : 29-01-2019

HGNC name	protein phosphatase 2, catalytic subunit, alpha isozyme
HGNC id	9299

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IDHE

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic marker in Colorectal cancer
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer PPP2CA and its regulatory subunits may be a therapeutic target for Alzheimer's disease cancer digestive colon therapeutic target in Colorectal cancer cancer bone   its inhibition could potentially suppress the malignancy of osteosarcoma cells diabete type 2   inhibition of hepatic PPP2CA may be a useful strategy for the treatment of insulin resistance syndrome

ANIMAL & CELL MODELS

double-transgenic Dom5/pR5 mice showed 7-fold increased numbers of hippocampal neurons that specifically phosphorylated the pathological S422 epitope of tau