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FLASH GENE

Symbol

RXRB

contributors: mct/npt - updated : 05-04-2019

HGNC name	retinoid X receptor, beta
HGNC id	10478

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal modulator domain
	a central bipartite (class II) zinc finger DNA binding domain
	a C terminal ligand domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Rxrb

Homologene

FAMILY	nuclear hormone receptor family
	nr2 subfamily

CATEGORY

transcription factor , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in mediating the effects of retinoic acid (RA)
	RXRB heterodimerized with aretinoic acid (RA) receptor-alpha (RARA) transduces signals required in Sertoli cells for spermatid release (Vernet 2008)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

obligate member of heterodimeric nuclear receptors

INTERACTION

DNA

binding

RNA

small molecule

protein

retinoic acid X receptor binding

cell & other

REGULATION

activated by

9-cis-retinoic acid,only (9-cis-RA)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Wegener Granulomatosis

Variant & Polymorphism other	strong association of the RXRB locus with Wegener Granulomatosis (Wieczorek 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760)

ANIMAL & CELL MODELS