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FLASH GENE

Symbol

RXRB

contributors: mct/npt - updated : 05-04-2019

HGNC name	retinoid X receptor, beta
HGNC id	10478

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.3      Physical location : 4.393.587 - 33.168.432
Synonym name	MHC class I promoter binding protein
	nuclear receptor subfamily 2 group B member 2
Synonym symbol(s)	NR2B2, DAUDI6, H-2RIIBP, RCoR-1, MGC1831

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
text	located just upstream of the alpha2(XI) collagen chain gene (Col11a2) in a head-to-tail manner (Murai 2008)
STRUCTURE	7.07 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	potential presence of enhancer-blocking elements that insulate RXRB promoter from the COL11A2 enhancer (Murai 2008)

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see KE@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021976 10 - 2892 NP_068811 - 533 - Fleischhauer (1992)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Endocrine pancreas         Nervous brain         Reproductive female system uterus       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal modulator domain
	a central bipartite (class II) zinc finger DNA binding domain
	a C terminal ligand domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Rxrb

Homologene

FAMILY	nuclear hormone receptor family
	nr2 subfamily

CATEGORY

transcription factor , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in mediating the effects of retinoic acid (RA)
	RXRB heterodimerized with aretinoic acid (RA) receptor-alpha (RARA) transduces signals required in Sertoli cells for spermatid release (Vernet 2008)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

obligate member of heterodimeric nuclear receptors

INTERACTION

DNA

binding

RNA

small molecule

protein

retinoic acid X receptor binding

cell & other

REGULATION

activated by

9-cis-retinoic acid,only (9-cis-RA)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Wegener Granulomatosis

Variant & Polymorphism other	strong association of the RXRB locus with Wegener Granulomatosis (Wieczorek 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760)

ANIMAL & CELL MODELS