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FLASH GENE

Symbol

HSPA1A

contributors: mct/pgu - updated : 02-03-2018

HGNC name	heat shock 70kDa protein 1A
HGNC id	5232

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   low expressed in gastric cancer constitutional     --over   in preeclampsia, and serum HSPA1A levels reflect systemic inflammation, oxidative stress and hepatocellular injury, but is significantly higher in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) than in severely preeclamptic patients without HELLP syndrome

Susceptibility

to coronary heart disease (CHD) to Meniere disease (MD)

Variant & Polymorphism other	+190CC genotype was associated with significantly higher risk of CHD
	frequency of having at least one 190C allele was significantly higher in the MD patients than the controls

Candidate gene
Marker
Therapy target	potential target for therapeutic treatment of obesity-induced insulin resistance
	System Type Disorder Pubmed neuromuscular myopathy   increasing the expression of HSPA1A in muscle has significant therapeutic potential for DMD and related conditions diabete     HSPA1A is a potential treatment to prevent Beta-cell mass decline in type 2 diabetic patients

ANIMAL & CELL MODELS