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FLASH GENE

Symbol

HLA-A

contributors: mct/npt - updated : 18-08-2009

HGNC name	major histocompatibility complex, class I, A
HGNC id	4931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002116 8 - 1538 NP_002107 38.2 365 - Krangel (1979)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Reproductive sperm cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three globular extracellular domains
	alpha 1 and alpha 2 forming the peptide binding groove and a I,C-like alpha 3 domain
	a single transmembrane domain
	a cytoplasmic tail

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

MHC class I family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

presenting short pathogen-derived peptide to T cells initiating the adaptative, then immune response

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

forming an heterodimer with beta 2 microglobular (B2M)

INTERACTION

DNA

RNA

small molecule

protein	binding for adequate complexion
	loaded by TAP molecules

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to nasopharyngeal carcinoma

Variant & Polymorphism other	HLA-A*0207 increasing the risk of nasopharyngeal carcinoma (Tse 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS