| protein
| PI3K |
|
SMAD1, SMAD2, SMAD3, SMAD4 |
|
NCOA3, NCOA5, NCOA6, NCOA7 |
|
PHB2, PECP1, UBE1C, AKAP13, CUEDC2, KDM5A, HEXIM1, MAP1S, PBXIP1 |
|
MUC1, DNTTIP2, FAM120B, UIMC1, TXNRD1, MLL2, ATAD2, KIF18A |
|
LDB1, RLIM, MACROD1, FOXL2, SH2D4A, PLCG, SLC30A9 |
|
BARX2 and ESR1 proteins bind to different ESR1 gene promoters and regulate the expression of alternatively spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms  |
|
SMYD3 functions as a coactivator of ESR1 and potentiates ESR1 activity in response to ligand |
|
FLII can bind directly to both ESR1 and ACTL6A, an actin-related component of the SWI/SNF complex, suggesting that FLII may recruit SWI/SNF to ESR1 target genes via interaction with ACTL6A |
|
NCOA2 interacts with ESR1, ESR2 and PGR in a subtype-specific manner, which may contribute to the functional differences of these steroid receptor subtypes in brain |
|
interacts with corepressor complexes, which normally consist of histone deacetylases (HDACs), to remove acetylation on histones, leading to gene repression |
|
estrogen induces the binding of the ESR1 onto the promoter of ZFHX3 and ZFHX3 is an ESR1 target gene |
|
ESR1, ESR2 coordinate with MLL and MLL3 in E2-mediated transcriptional regulation of HOXB9 |
|
role of FLI1 as a negative regulator of the ESR1 gene in dermal fibroblasts |
|
association of ESR1 and CRKL directly enhances the tumorigenic potential of CRKL, thus pointing to its role in cell proliferation |
|
cooperation of KAT5 with ESR1 and other chromatin-remodeling enzymes is required for estrogen-induced transcription |
|
KDM1A functions as a transcription coactivator of ESR1 and androgen receptor (AR) |
|
by destabilizing ESR1, RUNX3 acts as a novel tumor suppressor in breast cancer |
|
in breast cancer cells, NR5A2 promotes cell proliferation by enhancing ESR1 mediated transcription of target genes such as GREB1) |
|
ESR1 interacts with both SAFB1 and SAFB2 in the presence of E2 |
|
TP53 is a target gene of ESR1 (feedback loop between ESR1 and TP53 and a biological role of TP53 in the DNA damage response in ER-positive breast cancers) |
|
rapid, non-genomic changes in cardiac myofilament function following acute ESR1 stimulation mediated by the MAPK14 pathway |
|
ESR1 interacted with mitochondrial protein HADHB and affected the thiolytic cleavage activity of HADHB in beta-oxidation |
|
ESR1 regulation of its own mRNA expression is facilitated by RBCK1 recruitment, suggesting an ESR1 coactivator function of RBCK1 |
|
CACUL1 associated with histone demethylase KDM1A and suppressed KDM1A-enhanced ESR1 activity |
|
LATS2 modulates ESR1-regulated gene transcription, through direct and/or indirect interactions with ESR1 |
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HDAC3 is necessary for ESR1 mRNA stability, and is involved in the estrogen-dependent proliferation of ESR1-positive tumors |
|
GRB1 is a chromatin-bound ESR1 coactivator and is essential for ESR1-mediated transcription, because it stabilizes interactions between ESR1 and additional cofactors |
|
ESR1 coregulator PELP1 plays an important role in ESR1 signaling and is a proto-oncogene with aberrant expression in breast cancer |
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PELP1-CARM1 interactions synergistically enhance ESR1 transactivation |
|
PDZK1 expression was indirectly regulated by ESR1 stimulation, requiring IGF1R expression and function |
|
plays a crucial role in decreasing HIF1A protein levels in osteoclasts, even in hypoxic conditions ( |
|
PRL promotes pubertal ESR1-dependent mammary ductal elongation and gene expression in the absence of estrogen, which are abrogated by the antiestrogen |
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role for HOXA7 in modulating breast cancer cell proliferation via regulation of ESR1 expression |
|
SMYD2 directly methylates estrogen receptor alpha (ESR1) protein at lysine 266 and represses ESR1 transactivation activity |
|
SMYD2 attenuates ESR1 chromatin recruitment |
|
KDM1A cooperates with EP300 to facilitate ESR1 protein acetylation and target gene activation upon estrogen stimulation |
|
UBR5, a protein commonly amplified in breast cancer, is a novel regulator of ESR1 protein levels and transcriptional activity |
|
is a new epigenetic regulator of ESR1 activity and cellular differentiation |
|
ESR1 stimulates likely IBSP gene transcription in a ligand-independent manner by targeting the CRE and AP1/GRE elements in the IBSP gene promoter |
|
interactions between FOXP1 and ESR1 may play a pivotal role in the progression of ovarian cancer |
|
coupling between ESR1 and lipid raft CAV1 is critical for membrane ER signaling in synaptic plasticity and therefore, increased coupling of CAV1 and ESR1 may elucidate a critical abnormal mechanism of Fragile X syndrome (FRAXA) |
|
PINX1 interacts with the N-terminal domain of ESR1 and functions as a corepressor of ESR1 |
|
ESR1 interacts with DLX3 and increases its transcriptional activity and DNA binding affinity |
|
CCNE1/REL and TUBA1B/ESR1 might play pivotal roles in the occurrence and development of Postmenopausal osteoporosis |
|
WBP2 acts as a transcriptional coactivator for ESR1 and progesterone receptor (PGR) |
|
SRARP is an interacting partner of ESR1 |
|
crucial role of ESR1 for the mammalian female in regulating semen coagulation and liquefaction with KLK3 |
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because methylation represses ESR1 activity, the observed complex formation between SMYD2 and HSP90AA1/PTGES3 may contribute to ESR1 regulation |
|
SAFB and its paralogue, SAFB2, are nuclear matrix-binding proteins that negatively modulate ESR1-mediated transcription |
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binding of ESR1 is crucial for chromatin remodeling of NR5A1 enhancer and promoter, leading to RNA polymerase recruitment and transcription |
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TNPO2 regulates nucleocytoplasmic shuttling and cytoplasmic retention of ESR1, so that ESR1 has precise functions depending on the stimulation |
|
likely ESR1 interacts with NFATC1 to repress WNT5B protein expression |
