| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| fusion
| translocation
|
|
|
|
Loss of PTEN and concomitant activation of AKTcould act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostatecancer |
| tumoral
|
|
| --over
|
|
overexpression in prostate tumor cells may contribute to the neoplastic process by activating MYC and by abrogating prostate epithelial differentiation as indicated by prostate epithelial specific markers  |
| tumoral
| fusion
|
|
|
|
|
NDRG1-ERG fusion in prostate carcinoma is predicted to encode a chimeric protein |
| tumoral
| fusion
|
|
|
|
|
TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia (P |
| tumoral
|
|
| --over
|
|
|
may deregulate several signaling cascades in acute leukemia |
| tumoral
| fusion
|
|
|
|
|
TMPRSS2-ERG gene fusions were observed in 44p 100 of prostate cancer, and over 90p100 of these fusions occurred in ERG exons 3 or 4 |
