| basic FUNCTION
| degrading the catecholamine and inactivating catechol drugs in the central nervous system |
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important modulator in the catabolism of extraneural dopamine, which plays an important role in drug reward mechanisms |
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having a major function in regulating epinephrine, norepinephrine, and dopamine levels in the brain, particularly in the prefrontal cortex |
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regulating dopamine levels in the brain |
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plays a particular role in modulating dopamine in prefrontal cortex  |
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may have a general homeostatic role in regulating several genes, such as SLC6A3, to enhance dopaminergic signaling |
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key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens |
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dominates the regulation of dopamine metabolism in the prefrontal cortex |
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COMT effects are particularly evident in prefrontal cortex-dependent cognitive functions including executive control, working memory, attentional control and long-term memory |
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contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself |
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role of APOE and COMT genes in prospective and retrospective memory traits |
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one of the most important enzymes involved in estrogen metabolism |
