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FLASH GENE
Symbol CD8A contributors: mct/npt - updated : 28-03-2012
HGNC name CD8a molecule
HGNC id 1706
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   predominantly
 thymus   predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • enhancing formation of stable T-cell receptor/MHC class I complexes
  • enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling
  • interplay between CD8A+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses
  • its expression is tightly controlled during T-cell development by the activity of five CD8 enhancers (E8(I)-E8(V)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with CD8B, forms CD8alphabeta heterodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with NFIL3 (plays an essential role in the development of CD8A(+) conventional dendritic cells)
  • interacting with LNX1 or LNX2 (LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS