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FLASH GENE

Symbol

CD8A

contributors: mct/npt - updated : 28-03-2012

HGNC name	CD8a molecule
HGNC id	1706

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p11.2      Physical location : 87.011.728 - 87.035.519
Synonym name	CD8 antigen, alpha polypeptide (p32)
	Leu2 T-lymphocyte antigen
	OKT8 T-cell antigen
	T cell co-receptor
	cell differentiation antigen CD8A (p32), class I receptor, identified by monoclonal antibodies T8, Leu2a, M236, UCHT4, T811
Synonym symbol(s)	CD8, LEU2, MAL, p32

DNA

TYPE	functioning gene
STRUCTURE	7.11 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	pter - CD8A - IGKC IGKC - IGKJ@ - IGKV@ - cen
Authors	Weichhold (93)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001768 5 - 3035 NP_001759 - 235 - 2007 17678538 NM_171827 5 - 2924 NP_741969 - 198 - 2007 17678538 NM_001145873 - - 3177 NP_001139345 - 235 - 2007 17678538

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       predominantly   thymus       predominantly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	enhancing formation of stable T-cell receptor/MHC class I complexes
	enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling
	interplay between CD8A+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses
	its expression is tightly controlled during T-cell development by the activity of five CD8 enhancers (E8(I)-E8(V)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

with CD8B, forms CD8alphabeta heterodimer

INTERACTION

DNA

RNA

small molecule

protein	interaction with NFIL3 (plays an essential role in the development of CD8A(+) conventional dendritic cells)
	interacting with LNX1 or LNX2 (LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS