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FLASH GENE
Symbol CMA1 contributors: mct - updated : 12-03-2007
HGNC name chymase 1, mast cell
HGNC id 2097
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cma1
Homologene
FAMILY
  • trypsin family
  • granzyme subfamily
  • peptidase family S1
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease, cleaving chymotrypsin
  • degradation of the extracellular matrix, regulation of submucosal gland secretion, and generation of vasoactive peptides
  • largely responsible in the heart and blood vessels, for converting angiotensin I to the vasoactive peptide angiotensin II
  • activated human skin mast cells (MCs) convert CTAP-III into biologically active NAP-2 through proteolytic cleavage by released chymase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chymotrypsin
  • Human mast cell chymase caused conjunctival epithelial cell detachment by degrading fibronectin, and this led to secondary apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atopy
    Variant & Polymorphism a variant putatively involved in eczema
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS