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FLASH GENE

Symbol

AVP

contributors: mct - updated : 02-04-2016

HGNC name	arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
HGNC id	894

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DIR3 diabetes insipidus, neurohypophyseal type
Location	20p13      Physical location : 3.063.202 - 3.065.370
Genatlas name	copeptin
Synonym name	vasopressin-neurophysin 2-copeptin
Synonym symbol(s)	ARVP, ADH, AVP-NPII, VP

DNA

TYPE	functioning gene
STRUCTURE	2.17 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see OXT

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000490 3 - 621 NP_000481 - 164 - 2005 16006166

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol endocrine brain diencephalon pituitary     Nervous brain diencephalon hypothalamus supraoptic nuclei   Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol not specific neuroendocrine cell

cell lineage
cell lines
fluid/secretion	secreted

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

Copeptin, is the C-terminal part of the vasopressin prohormone

isoforms

Precursor

arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin

HOMOLOGY

Homologene

FAMILY

vasopressin/oxytocin family

CATEGORY

secretory , signaling hormone

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	neurosecretory vesicles

basic FUNCTION	acting as a growth factor by enhancing pH regulation through acid-base transport systems
	having a direct antidiuretic action on the kidney, and also causing vasoconstriction of the peripheral vessels
	adjusts the amount of AQP2 in the plasma membrane by triggering its redistribution from intracellular vesicles into the plasma membrane
	enhances AQP2 protein abundance by altering its proteasomal degradation through a PRKA- and MAPK14-dependent pathway
	affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein	recruited AQP2, but also AKAP7Vdelta to the plasma membrane
	interacting with AQP2 (modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water)
	binds to AVPR2, increasing cAMP, which promotes the redistribution of AQP2 from intracellular vesicles into the plasma membrane

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DIR3

related resource

Neprhogenic diabetes Insipidus

Susceptibility

to diabetes mellitus

Variant & Polymorphism other	elevated copeptin predicts increased risk for diabetes mellitus independently of established clinical risk factors, including fasting glucose and insulin

Candidate gene
Marker	copeptin is a new promising prognostic marker for short-term mortality independently and additive to natriuretic peptide levels in patients with acute dyspnea
	ischemia-modified albumin (IMA) and AVP detection is clinically useful in the early diagnosis and prognosis of acute carbon monoxide poisoning (ACOP)-related myocardial injury and in guiding early clinical drug application
	AVP and ENO2 measured in the early postnatal period are potential prognostic biomarkers of long-term neurodevelopmental outcome in term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma   AVP system may be a therapeutic target in post-myocardial infarction left ventricular dysfunction

ANIMAL & CELL MODELS