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FLASH GENE
Symbol AVP contributors: mct - updated : 02-04-2016
HGNC name arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
HGNC id 894
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 621 - 164 - 2005 16006166
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Nervousbraindiencephalonhypothalamussupraoptic nuclei 
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
not specificneuroendocrine cell
cell lineage
cell lines
fluid/secretion secreted
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Copeptin, is the C-terminal part of the vasopressin prohormone
  • isoforms Precursor arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin
    HOMOLOGY
    Homologene
    FAMILY vasopressin/oxytocin family
    CATEGORY secretory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • neurosecretory vesicles
  • basic FUNCTION
  • acting as a growth factor by enhancing pH regulation through acid-base transport systems
  • having a direct antidiuretic action on the kidney, and also causing vasoconstriction of the peripheral vessels
  • adjusts the amount of AQP2 in the plasma membrane by triggering its redistribution from intracellular vesicles into the plasma membrane
  • enhances AQP2 protein abundance by altering its proteasomal degradation through a PRKA- and MAPK14-dependent pathway
  • affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruited AQP2, but also AKAP7Vdelta to the plasma membrane
  • interacting with AQP2 (modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water)
  • binds to AVPR2, increasing cAMP, which promotes the redistribution of AQP2 from intracellular vesicles into the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIR3
    related resource Neprhogenic diabetes Insipidus
    Susceptibility to diabetes mellitus
    Variant & Polymorphism other
  • elevated copeptin predicts increased risk for diabetes mellitus independently of established clinical risk factors, including fasting glucose and insulin
  • Candidate gene
    Marker
  • copeptin is a new promising prognostic marker for short-term mortality independently and additive to natriuretic peptide levels in patients with acute dyspnea
  • ischemia-modified albumin (IMA) and AVP detection is clinically useful in the early diagnosis and prognosis of acute carbon monoxide poisoning (ACOP)-related myocardial injury and in guiding early clinical drug application
  • AVP and ENO2 measured in the early postnatal period are potential prognostic biomarkers of long-term neurodevelopmental outcome in term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia
  • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    AVP system may be a therapeutic target in post-myocardial infarction left ventricular dysfunction
    ANIMAL & CELL MODELS