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FLASH GENE

Symbol

AHSG

contributors: mct - updated : 15-12-2015

HGNC name	alpha-2-HS-glycoprotein
HGNC id	349

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   is correlated with the development of cardiovascular diseases (CVD) constitutional     --low   decreased serum AHSG levels were independently associated with disease activity in patients with Crohn disease and ulcerative colitis constitutional     --low   in patients with Alzheimer, disease in proportion to the severity of cognitive impairment constitutional     --low   nephrolithiasis patients had lower AHSG protein level in urine and renal tissue constitutional     --low   AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls constitutional     --over   in diabetes patients with nonalcoholic fatty liver disease (NAFLD) constitutional     --low   serum AHSG concentration is decreased and reflects-at least partly-systemic inflammation in preeclampsia

Susceptibility

to low body mass index

Variant & Polymorphism SNP	SNP associated to low body mass index
	variant Thr230Met associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in body weight regulation

Candidate gene
Marker	may serve as a biological link between vascular disease and normal age-related cognitive decline
	biomarker reported to be important in many metabolic disorders, including obesity, diabetes, and hepatic steatosis
Therapy target

ANIMAL & CELL MODELS

Fetuin-A deficiency in mice resulted in decreased hepcidin mRNA levels