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Symbol AHSG contributors: mct - updated : 15-12-2015
HGNC name alpha-2-HS-glycoprotein
HGNC id 349
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
is correlated with the development of cardiovascular diseases (CVD)
constitutional     --low  
decreased serum AHSG levels were independently associated with disease activity in patients with Crohn disease and ulcerative colitis
constitutional     --low  
in patients with Alzheimer, disease in proportion to the severity of cognitive impairment
constitutional     --low  
nephrolithiasis patients had lower AHSG protein level in urine and renal tissue
constitutional     --low  
AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls
constitutional     --over  
in diabetes patients with nonalcoholic fatty liver disease (NAFLD)
constitutional     --low  
serum AHSG concentration is decreased and reflects-at least partly-systemic inflammation in preeclampsia
Susceptibility to low body mass index
Variant & Polymorphism SNP
  • SNP associated to low body mass index
  • variant Thr230Met associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in body weight regulation
  • Candidate gene
  • may serve as a biological link between vascular disease and normal age-related cognitive decline
  • biomarker reported to be important in many metabolic disorders, including obesity, diabetes, and hepatic steatosis
  • Therapy target
  • Fetuin-A deficiency in mice resulted in decreased hepcidin mRNA levels