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FLASH GENE

Symbol

ADRA2C

contributors: mct - updated : 12-03-2008

HGNC name	adrenergic, alpha-2C-, receptor
HGNC id	283

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	1.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D4S95 - HD - D4S125 - D4S126 - D4S81 - ADRA2C - D4S10 - cen
Authors	Riess (94)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive female system breast mammary gland       female system placenta         female system ovary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons
	involved in cold-induced constriction of cutaneous arteries

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

17beta-estradiol by interacting with cell surface receptors (cause a cAMP/Rap2-dependent increase in ADRA2C transcription)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may contribute to pathological changes in vascular function

Susceptibility

to congestive heart failure

Variant & Polymorphism SNP	increasing the risk of congestive heart failure

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS