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FLASH GENE

Symbol

ACR

contributors: mct - updated : 21-01-2025

HGNC name	acrosin
HGNC id	126

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF87

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function is associated with sperm function anomaly and poor outcomes of in vitro fertilization

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   is an attractive target for the discovery of novel male contraceptives

ANIMAL & CELL MODELS

	KO acrosin-deficient mice exhibit normal fecundity except for delayed fertilization
	litter size from acrosin-disrupted males was decreased compared to heterozygous mutant rats