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FLASH GENE

Symbol

MST1

contributors: mct/npt/pgu - updated : 02-04-2020

HGNC name	macrophage stimulating 1 (hepatocyte growth factor-like)
HGNC id	7380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   reduced expression was observed in many types of cancer, including large-cell lung carcinoma tumoral   deletion     attenuated cerebral ischemia-reperfusion (IR) injury by improving mitochondrial function and reducing mitochondrial damage

Susceptibility

to Crohn disease

Variant & Polymorphism SNP	A>G at rs144982232 in MST1 showed the most significant association with Crohn's disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast potential target for the development of novel breast cancer therapies

ANIMAL & CELL MODELS