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FLASH GENE
Symbol MST1 contributors: mct/npt/pgu - updated : 02-04-2020
HGNC name macrophage stimulating 1 (hepatocyte growth factor-like)
HGNC id 7380
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal kinase domain
  • four cysteine-rich kringle domains
  • heterodimeric transmembrane glycoprotein (beta=150kD, alpha=35kD)
  • two carboxy-terminal nuclear export signals (NES)
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to hippo
    intraspecies paralog to HGF
    Homologene
    FAMILY
  • peptidase S1 family
  • plasminogen subfamily
    • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating macrophage migration, phagocytosis, and nitric oxide production
  • involved in the regulation of peripheral macrophage activation
  • has the potential to modulate inflammatory actions of microglia, which proposes novel aspects for the process of degeneration and/or regeneration of the brain
  • protein regulating the innate immune responses to bacterial ligands and may have a role in the pathogenesis of inflammatory bowel diseases
  • MST1/MST1R signaling seems to play at least some role in the pathogenesis of Merkel cell carcinoma
  • may be one of the major determinants that affects the properties of tumor stroma and that produces a permissive microenvironment to promote cancer metastasis
  • is a positive regulator of mammary gland ductal morphogenesis by controlling overall epithelial cell turnover, macrophage recruitment, and STAT3 activation in the developing mammary gland
  • MST1/MST1R play important roles in inflammation, cell growth, migration, and epithelial to mesenchymal transition during tumor development
  • appears to promote the migration of fibroblasts, enhances collagen synthesis and remodeling, and effectively improves wound healing
  • hepatokine that potentially has a beneficial role in hepatic lipid and glucose metabolism via the activation of AMP-activated protein kinase (AMPK)
  • is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that it has a key regulatory role in Non-alcoholic steatohepatitis (NASH)
  • MST1 controlled inflammation response and mitochondrial function in endothelial cells
  • MST1 is the primary factors responsible for endothelial cells dysfunction in aneurysms formation through inducing inflammation response, endothelial apoptosis, and NFKB1 signaling pathway activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MST1/MST1R system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MST1R ligand
  • interacting with RCC1 (RCC1 immobilization on the chromosomes at early stages of apoptosis is dependent on MST1 and its phosphorylation of histone H2B)
  • major determinant of RASSF2 protein stability
  • interacts strongly with RASSF5 but only weakly other components of the mammalian Hippo signaling pathway
  • TMPRSS11D is likely important for MST1-MST1R signaling in the respiratory tract
  • SAFB bound to AR and phosphorylated by MST1, previously shown to be an AR repressor, and MST1 localization to AR-dependent promoters was inhibited by SAFB depletion
  • through binding to its receptor, RON or MST1R), it can activate epithelial cells and work as an inflammatory mediator
    • cell & other
    REGULATION
    Other MST1 kinase activity is regulated by RASSF2 via RASSF2-MST1 protein complex formation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    reduced expression was observed in many types of cancer, including large-cell lung carcinoma
    tumoral   deletion    
    attenuated cerebral ischemia-reperfusion (IR) injury by improving mitochondrial function and reducing mitochondrial damage
    Susceptibility to Crohn disease
    Variant & Polymorphism SNP
  • A>G at rs144982232 in MST1 showed the most significant association with Crohn's disease
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential target for the development of novel breast cancer therapies
    ANIMAL & CELL MODELS