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FLASH GENE
Symbol HOXD1 contributors: mct/npt/pgu - updated : 11-09-2009
HGNC name homeobox D1
HGNC id 5132
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain, homeobox domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.9
    homolog to Drosophila lab
    Homologene
    FAMILY
  • ANTP family of homeobox protein
  • labial subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in both axial patterning and limb morphogenesis
  • possible role for HOXD1 in the ovarian oocytes and the establishment of mesodermal derivatives during embryogenesis
  • potential synergy between MEIS3 and HOXD1 in HOXD1 autoregulation in mesoderm during gastrulation
  • plays a significant role in endothelial cells functions by regulating the expression of ITGB1
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MOG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS