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FLASH GENE

Symbol

HOXD1

contributors: mct/npt/pgu - updated : 11-09-2009

HGNC name	homeobox D1
HGNC id	5132

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024501 2 - 1991 NP_078777 - 328 - 2000 11060466

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       predominantly Homo sapiens Nervous brain       moderately Urinary kidney       highly

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain, homeobox domain

HOMOLOGY

interspecies	homolog to murine Hox-4.9
	homolog to Drosophila lab

Homologene

FAMILY	ANTP family of homeobox protein
	labial subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in both axial patterning and limb morphogenesis
	possible role for HOXD1 in the ovarian oocytes and the establishment of mesodermal derivatives during embryogenesis
	potential synergy between MEIS3 and HOXD1 in HOXD1 autoregulation in mesoderm during gastrulation
	plays a significant role in endothelial cells functions by regulating the expression of ITGB1

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with MOG

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS