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FLASH GENE

Symbol

HOXD11

contributors: mct/npt - updated : 16-03-2009

HGNC name	homeobox D11
HGNC id	5134

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	2.23 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HOXD11 2 - 1463 35.1 338 - Boulet (2002)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-4.6
	ortholog to murine Hoxd11
	homolog to C.elegans B0412.1

Homologene

FAMILY

Abd-B homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing an important role in morphogenesis in all multicellular organisms
	may be playing a role in metanephric kidney development within the intermediate mesoderm (Mugford 2008)
	suppresses the expression of HOXD10 and the retinoic acid synthetic enzyme, retinaldehyde dehydrogenase 2 (RALDH2) (Misra 2009)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PSDY2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by aberrant promoter methylation in ovarian cancers (Cai 2007) constitutional   deletion     of the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities tumoral fusion       to NUP98 in acute myeloid leukemia with t(2;11)(q31;p15)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS