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FLASH GENE
Symbol ITGB6 contributors: mct - updated : 28-05-2008
HGNC name integrin, beta 6
HGNC id 6161
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • a globular domain
  • a stalk region with seven EGF-like repeats each with eight cysteine residues
  • a single transmembrane domain (1TM)
  • a short cytoplasmic tail
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin beta chain family
    • CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGAV in fibronectin receptor (tail)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITGAV (RGD-dependent receptor for Coxsackievirus A9 CAV9 and may be important in natural CAV9 infections)
  • binds and activates latent TGFbeta3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q24
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS