Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ITGB6 contributors: mct - updated : 28-05-2008
HGNC name integrin, beta 6
HGNC id 6161
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   highly
Endocrinepancreas   highly
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • a globular domain
  • a stalk region with seven EGF-like repeats each with eight cysteine residues
  • a single transmembrane domain (1TM)
  • a short cytoplasmic tail
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin beta chain family
  • CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGAV in fibronectin receptor (tail)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITGAV (RGD-dependent receptor for Coxsackievirus A9 CAV9 and may be important in natural CAV9 infections)
  • binds and activates latent TGFbeta3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q24
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS