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FLASH GENE

Symbol

ITGB6

contributors: mct - updated : 28-05-2008

HGNC name	integrin, beta 6
HGNC id	6161

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	98.36 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000888 15 - 2397 NP_000879 - 788 - 2008 18349127

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine       highly Endocrine pancreas       highly Respiratory lung       highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide
	a globular domain
	a stalk region with seven EGF-like repeats each with eight cysteine residues
	a single transmembrane domain (1TM)
	a short cytoplasmic tail

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

integrin beta chain family

CATEGORY

adhesion , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dimerizing with ITGAV in fibronectin receptor (tail)

INTERACTION

DNA

RNA

small molecule

protein	ITGAV (RGD-dependent receptor for Coxsackievirus A9 CAV9 and may be important in natural CAV9 infections)
	binds and activates latent TGFbeta3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q24

Susceptibility

to type 2 diabetes

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS