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FLASH GENE

Symbol

CALM2

contributors: mct - updated : 14-05-2019

HGNC name	calmodulin 2 (phosphorylase kinase, delta)
HGNC id	1445

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.85 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001743 6 - 1210 NP_001734 - 149 - 2016 27516456 NM_001305625 6 - 1236 NP_001292554 - 113 - 2016 27516456 NM_001305624 6 - 1377 NP_001292553 - 197 - - NM_001305626 6 - 4591 NP_001292553 - 197 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   salivary gland       highly Endocrine neuroendocrine pituitary     highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two Eps15 homology domains with four EF-hand calcium binding domains

HOMOLOGY

Homologene

FAMILY

calmodulin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus

basic FUNCTION	phosphorylase kinase, delta, calcium modulated protein
	mediates the control of a large number of enzymes and other proteins by Ca(2+)
	playing a crucial role in the processes of Ca(2+)-induced neuronal cell death and likely the blockage of calmodulin attenuates brain injury after cerebral ischemia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	interacts with TTN/titin and SRY
	could regulate the intramolecular interaction between the SH3, HOOK, and GK domains of DLG1
	interaction between RAB3B and calmodulin, Ca(2+)-dependent (RAB3B is primarily localized with the particulate fraction and Ca(2+)/calmodulin could regulate function of this GTPase in the platelet)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LQT15

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   might represent an attempt by the placenta to compensate for elevations in intracellular calcium, possibly caused by hypoxia and/or apoptosis, in both pregnancies with uterine artery notching and preeclampsia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive liver   CALM2 may serve as novel targets for the treatment of liver fibrosis

ANIMAL & CELL MODELS