| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| deletion
|
|
| |
in colon carcinoma, hepatoma cell lines and primary colon cancers | | constitutional
| germinal mutation
|
|
|
| |
associated with developmental defects | | tumoral
|
|
| --over
|
|
in several different types of human carcinomas with a differential modulation in embryonal and colon cancer cells by two different members of the TGF-beta family  | | tumoral
|
|
| --over
|
| |
contributes to aggressiveness and poor prognosis of hepatocellular carcinoma | | constitutional
|
|
|
| loss of function
| |
have been shown to result in holoprosencephaly | |
