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FLASH GENE
Symbol TDGF1 contributors: mct - updated : 22-11-2016
HGNC name teratocarcinoma-derived growth factor 1
HGNC id 11701
ASSOCIATED DISORDERS
corresponding disease(s) HPEL1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in colon carcinoma, hepatoma cell lines and primary colon cancers
constitutional germinal mutation      
associated with developmental defects
tumoral     --over  
in several different types of human carcinomas with a differential modulation in embryonal and colon cancer cells by two different members of the TGF-beta family
tumoral     --over  
contributes to aggressiveness and poor prognosis of hepatocellular carcinoma
constitutional       loss of function
have been shown to result in holoprosencephaly
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be an attractive target in the diagnosis, prognosis and therapy of several types of human cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    disrupting the TDGF1/HSPA5 binding interface blocks oncogenic TDGF1 signaling and may have important therapeutic value in the treatment of cancer
    ANIMAL & CELL MODELS