| basic FUNCTION
| playing a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm |
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implicated in midline forebrain and left-right axis development |
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can activate mitogen-activated protein kinase (MAPK), AKT and c-src intracellular signaling pathways independently of Nodal and ALK4 |
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function as a ligand through a Nodal/ALK4-independent signaling pathway that involves binding to glypican-1 and the subsequent activation through SRC of phosphoinositol-3 kinase/Akt and ras/mitogen-activated protein kinase intracellular pathways |
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may be involved in stem cell maintenance |
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can stimulate endothelial cell sprouting through direct cell-cell interaction, and may contribute to endothelial cell migration and possibly tumor angiogenesis |
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angiogenic and oncogenic effects might be enhanced by its shedding and shedding of TDGF1 could be a potential target for cancer therapy |
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glycosylphosphatidylinositol-anchored signaling protein with important roles during embryonic development, stem cell function and cancer progression  |
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plays a key role in stem cell biology and during early embryonic development |
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with HSPA5 bind at the cell surface to enhance tumor growth via the inhibition of TGF-beta signaling |
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capable of signaling through the Nodal pathway |
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plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors |
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facilitates Nodal signaling and inhibits activin signaling by forming receptor complexes with these ligands that are structurally and functionally similar |
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with HSPA5, cooperatively regulate signaling via activin-A, activin-B, TGFB-1 and NODAL |
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both TDGF1 and CFC1 function non-cell-autonomously during normal development |
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plays a role in the malignant transformation of the oral mucosa and is involved in the tumorigenesis and progression of oral squamous cell carcinoma by promoting the growth and migration of malignant cells |
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may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program |
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is implicated in multiple cellular events, including cell proliferation, motility and angiogenesis, through the activation of an intricate network of signaling pathways |
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is the key GPI anchored protein whose altered function results likely in an holoprosencephaly-like phenotype |
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TDGF1 and its cell-surface receptor HSPA5 are regulators of stem cell behavior in isolated fetal and adult mammary epithelial cells |
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is a multifunctional embryonic protein that is re-expressed during inflammation, wound repair, and malignant transformation |
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mediate cell growth, migration, invasion, and induce epithelial to mesenchymal transition (EMT) |
