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FLASH GENE
Symbol CEBPB contributors: mct/npt/pgu - updated : 04-01-2015
HGNC name CCAAT/enhancer binding protein (C/EBP), beta
HGNC id 1834
Location 20q13.13      Physical location : 48.807.375 - 48.809.212
Synonym name
  • liver-enriched transcriptional activator protein
  • nuclear factor of interleukin 6
  • interleukin 6-dependent DNA-binding protein
  • transcription factor 5
  • Synonym symbol(s) IL6DPB, TCF5, NFIL6, LAP, CRP2, C/EBP-beta, MGC32080
    DNA
    TYPE functioning gene
    STRUCTURE 1.84 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer   transcription factor
    text structure
  • several potential transcription factor-binding elements explaining the molecular basis of the activation of the human NF-IL6 gene by signaling molecules that control the immune and inflammatory responses
  • unfolded protein response element downstream of the protein coding sequence
  • MAPPING cloned Y linked N status confirmed
    Physical map
    ARFGEF2 20q13.13 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) SNAP23P 20 synaptosomal-associated protein, 23kDa pseudogene CSE1L 20q13 CSE1 chromosome segregation 1-like (yeast) STAU 20q13.1 staufen, RNA binding protein (Drosophila) ARPC3B 20q13.13 actin related protein 2/3 complex, subunit 3B, 21kDa DDX27 20q13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 KIAA1404 20q13.13 KIAA1404 protein KCNB1 20q13.1 potassium voltage-gated channel, Shab-related subfamily, member 1 PTGIS 20q13.1-q13.3 prostaglandin I2 (prostacyclin) synthase B4GALT5 20q13.1-q13.2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 SNRPFP1 20 small nuclear ribonucleoprotein polypeptide F pseudogene 1 SLC9A8 20q13.13 solute carrier family 9 (sodium/hydrogen exchanger), isoform 8 SPATA2 20q13.1-q13.2 spermatogenesis associated 2 ZNF313 20q13.13 zinc finger protein 313 LOC391256 20 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SNAI1 20q13.2 snail homolog 1 (Drosophila) LOC149738 20q13.13 hypothetical LOC149738 UBE2V1 20q13.2 ubiquitin-conjugating enzyme E2 variant 1 CEBPB 20q13.1 CCAAT/enhancer binding protein (C/EBP), beta COX6CP2 20 cytochrome c oxidase subunit VIc pseudogene 2 PTPN1 20q13.1-q13.2 protein tyrosine phosphatase, non-receptor type 1 LOC200230 20q13.13 similar to KIAA0386 C20orf175 20 chromosome 20 open reading frame 175 RPL36P2 20q13.1 ribosomal protein L36 pseudogene 2 PARD6B 20q13.13 par-6 partitioning defective 6 homolog beta (C. elegans) BCAS4 20q13.13-q13.2 breast carcinoma amplified sequence 4 TMSL6 20 thymosin-like 6 ADNP 20q13.3-q13.2 activity-dependent neuroprotector PSMD10P 20q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene DPM1 20q13.13 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit MOCS3 20 molybdenum cofactor synthesis 3 KCNG1 20q13 potassium voltage-gated channel, subfamily G, member 1 LAMR1P1 20q13.3 laminin receptor 1 pseudogene 1 NFATC2 20q13.2-q13.31 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
    RNA
    TRANSCRIPTS type messenger
    text two alternative forms LAP (liver-enriched transcriptional activator) and LIP -liver-enriched transcriptional inhibitory protein) (PMID: 8367486)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1837 - 345 - 1991 1889804
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
     stomach   highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    not specificadipocyte Homo sapiens
    cell lineage preadipocytes
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) protein
  • four TAD domains
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cebpb
    intraspecies homolog to CEBPG
    Homologene
    FAMILY
  • bZIP family
  • C/EBP subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text expressed in the satellite cells of healthy muscle
    basic FUNCTION
  • CCAAT enhancer binding protein beta, inducing conjointly with CEBPD
  • required for adipocyte differentiation
  • transcription factor 5 (interleukin-6-dependent DNA-binding protein, liver activator protein)
  • regulator of cell growth, differentiation and in promoting tumor invasiveness
  • critical downstream mediator of MApK1/MAPK3 activation
  • may be playing a possible role for in endometrial receptivity
  • playing a critical role in a novel IFN-induced cell growth-suppressive pathway via DAPK1 (binds to the promoter of DAPK1 and is required for the regulation of DAPK1)
  • important regulator of cytokine expression in human neutrophils
  • central role in regulating CD1d transcription
  • key factor responsible for inhibition of GFER mRNA expression
  • recruited to the PCK2 promoter during ER stress and is reversed by pre-treatment with a JNK inhibitor that relieves ER stress
  • stimulates PDK4 expression and participates in the T(3) induction of the CPT1A and PDK4 genes
  • potential role of CEBPB in the processes of adult hippocampal neurogenesis
  • CEBPB, CEBPA and ZFPM1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages
  • is involved in several cellular processes, such as proliferation, differentiation, and energy metabolism
  • key transcription factor regulating monocytic gene expression
  • essential role in the mesenchymal compartment in pulmonary fibrosis that is independent of its effects on inflammation or immune cell infiltration
  • critical regulator of IgG immune complex-induced inflammatory responses and injury in the lung
  • inhibits myogenic differentiation and its levels must be reduced to allow for activation of MYOD1 target genes and the progression of differentiation
  • novel function in regulating autophagy and reveal the mechanism of autophagy during adipocyte differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimers with CEBPA, CEBPD, CEBPG
  • INTERACTION
    DNA binding to CCAAT enhancer
    RNA
    small molecule
    protein
  • binding to an IL1-responsive element of the IL6 gene
  • CEBPB and promoting IL1B repression by heat shock factor 1(HSF1)
  • interacting with DLX3 for its basal regulation
  • TRIB1 is a negative regulator of CEBPB protein expression and modulates CEBPB-dependent gene expression in TLR-mediated signaling
  • interaction with KLF4 (binds directly to the C/EBPbeta (CEBPB) promoter and, together with EGR2, cooperatively transactivates a CEBPB reporter
  • is a direct substrate of EHMT2-mediated post-translational modification that alters the functional properties of CEBPB during gene regulation
  • MAPK1/MAPK3 and CEBPB constitute an LH-regulated signaling pathway that controls ovulation- and luteinization-related events
  • binds to the CCAAT box in the CD1D promoter
  • directly interact with DAXX after overexpression as well as on the endogenous level, and its activity is negatively regulated by the transcriptional co-repressor DAXX
  • evolutionarily conserved TAD4 domain of CEBPB is the target of the GADD45B-dependent signaling
  • interacting with FOXA1 (plays a suppressive role in the early phase of adipogenesis, acting under the control of CEBPB, and might be involved in the regulation of the rate of progression of the early phase of adipogenesis)
  • induced PDK4 gene expression and decreased PDC activity)
  • functional and coordinated role for RUNX1 and CEBPB transcription factors during activation of P2RX3 gene transcription
  • TNIP1 is an essential anti-inflammatory component of TLR-signaling pathways that controls CEBPB activity
  • CEBPB and RUNX2 cooperatively enhanced promoter activity of MMP13 through specific binding to a CEBP-binding motif and an osteoblast-specific cis-acting element 2 motif as a protein complex
  • RUNX2 is the most potent transcriptional partner of CEBPB in chondrocytes
  • EPAS1, is a potent and functional inducer of CEBPB expression in chondrocytes by the CEBPB promoter assay
  • directly interacts with BAZ1A
  • functional interaction between CEBPB and SMARCA5/BAZ1A, characterized mainly by suppression of CEBPB transactivation activity in the presence of SMARCA5 and BAZ1A
  • transcriptional repressor of ATF4 during UV stress (binds to critical elements in the ATF4 promoter, resulting in its transcriptional repression)
  • functional role for CEBPB in PTGES gene regulation and interaction between EGR1 and CEBPB highlights the proximal promoter co-operation with a novel distal enhancer element in regulating inducible PTGES expression
  • CEBPB is a novel regulator of P2RY2 expression
  • novel feed forward mechanism involving CEBPB and KDM4B in the regulation of mitotic clonal expansion by controlling cell cycle gene expression
  • methylated C bases in the CEBPB promoter relate to expression of the CEBPB gene, and its demethylation is linked with GATA2 protein association
  • ATG4B is a target gene of CEBPB and plays an important role in 3T3-L1 adipocyte differentiation
  • PIAS1 functions as a SUMO E3 ligase of CEBPB to regulate adipogenesis
  • ATF6 in association with the transcription factor CEBPB, regulates IFNG-induced expression of DAPK1
  • dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of CEBPB and CEBPD and direct transcriptional activation of PPARG2 and CEBPA during adipocyte differentiation
  • cell & other
    REGULATION
    activated by MAPK3,MAPK1 and MAP3K1 in response to interferon gamma for regulated gene expression
    activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
    induced by in response to endoplasmic reticulum stress, such as glucose deprivation, or treatment of cells with tunicamycin or thapsigargin
    Other MTOR regulates osteoclast formation by modulating the CEBPB isoform ratio, which in turn affects osteoclastogenesis by regulating MAFB expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in many solid tumors including gastric cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    may be an attractive therapeutic target for ameliorating obesity-induced inflammatory responses
    ANIMAL & CELL MODELS
  • chimeric bone marrow mice transplanted with bone marrow lacking C/EBP(-/-) demonstrated reduced systemic and adipose tissue inflammatory markers, macrophage content, and maintained insulin sensitivity on high fat diet