| 1 | ACTR2, CEBPB, MMD, SPRED2
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| Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis.
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| Wang NN, Zhang Y, Jiang F, Zhu DL, Di CX, Hu SY, Chen XF, Zhi LQ, Rong Y, Ke X, Duan YY, Dong SS, Yang TL, Yang Z, Guo Y.
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| Am J Hum Genet. Apr 6;110(4):625-637. doi: 10.1016/j.ajhg.2023.02.012. Epub 2023 Mar 15. 2023
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| 2 | CEBPB, KDM6B
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| KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
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| Qin M, Han F, Wu J, Gao FX, Li Y, Yan DX, He XM, Long Y, Tang XP, Ren DL, Gao Y, Dai TY.
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| BMC Cancer. May 17;21(1):559. doi: 10.1186/s12885-021-08282-w. Erratum in: BMC Cancer. 2021 Aug 5;21(1):893. 2021
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| 3 | CEBPB, OSTN
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| C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes
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| Guo Q, Hu H, Liu X, Yang D, Yin Y, Zhang B, He H, Oh Y, Wu Q, Liu C, Gu N.
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| Am J Physiol Endocrinol Metab. Jun 1;316(6):E1081-E1092. doi: 10.1152/ajpendo.00478.2018. Epub 2019 Apr 9. 2019
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| 4 | CEBPA, CEBPB, CEBPD, JMJD6, PPARG
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| Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
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| Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.
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| Nucleic Acids Res 43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27.
2015
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| 5 | ATF6, CEBPB, DAPK1
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| Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1.
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| Gade P, Manjegowda SB, Nallar SC, Maachani UB, Cross AS, Kalvakolanu DV.
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| Mol Cell Biol 34(21):4033-48. doi: 10.1128/MCB.00397-14. Epub 2014 Aug 18.
2014
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| 6 | CEBPB, IL6, TMUB1
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| CCAAT/enhancer-binding protein β regulates interleukin-6-induced transmembrane and ubiquitin-like domain containing 1 gene expression in hepatocytes
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| Liu M, Yuan T, Liu H, Chen P
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| Mol Med Rep Oct;10(4):2177-83. doi: 10.3892/mmr.2014.2457. Epub 2014 Aug 6. 2014
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| 7 | ATG4B, CEBPB
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| Transactivation of Atg4b by C/EBPβ Promotes Autophagy to Facilitate Adipogenesis.
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| Guo L, Huang JX, Liu Y, Li X, Zhou SR, Qian SW, Liu Y, Zhu H, Huang HY, Dang YJ, Tang QQ.
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| Mol Cell Biol ol Cell Biol. 2013 Jun 10. [Epub ahead of print]
2013
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| 8 | CEBPB, GATA2
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| The methylation of C/EBP β gene promoter and regulated by GATA-2 protein.
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| Rui W, Jin Z, Zhe G, Song H.
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| Mol Biol Rep 40(2):797-801. doi: 10.1007/s11033-012-2117-7.
2013
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| 9 | CEBPB, PUAS1
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| Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein β (C/EBPβ) during adipogenesis.
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| Liu Y, Zhang YD, Guo L, Huang HY, Zhu H, Huang JX, Liu Y, Zhou SR, Dang YJ, Li X, Tang QQ.
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| Mol Cell Biol 33(22):4606-17. doi: 10.1128/MCB.00723-13. Epub 2013 Sep 23.
2013
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| 10 | CEBPB, CEBPG
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| C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ
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| Huggins CJ, Malik R, Lee S, Salotti J, Thomas S, Martin N, Quiñones OA, Alvord WG, Olanich ME, Keller JR, Johnson PF
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| Mol Cell Biol. Aug;33(16):3242-58. doi: 10.1128/MCB.01674-12. Epub 2013 Jun 17. 2013
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| 11 | CEBPB, PTGES
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| Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ.
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| Walters JN, Bickford JS, Newsom KJ, Beachy DE, Barilovits SJ, Herlihy JD, Nick HS.
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| Biochem J 443(2):561-71.
2012
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| 12 | ATF4, CEBPB
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| Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein â (C/EBPâ) differentially regulates integrated stress response.
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| Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC.
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| J Biol Chem 287(26):21936-49. doi: 10.1074/jbc.M112.351783. Epub 2012 May 3.
2012
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| 13 | CEBPB
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| Mesenchymal-specific deletion of C/EBPâ suppresses pulmonary fibrosis.
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| Hu B, Wu Z, Nakashima T, Phan SH.
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| Am J Pathol 180(6):2257-67. doi: 10.1016/j.ajpath.2012.02.010. Epub 2012 Apr 11.
2012
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| 14 | CEBPB
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| Regulation of C/EBPâ and resulting functions in cells of the monocytic lineage.
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| Huber R, Pietsch D, Panterodt T, Brand K.
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| Cell Signal 24(6):1287-96. doi: 10.1016/j.cellsig.2012.02.007. Epub 2012 Feb 22. Review.
2012
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| 15 | CEBPB
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| CCAAT/Enhancer Binding Protein Beta is Expressed in Satellite Cells and Controls Myogenesis.
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| Marchildon F, Lala N, Li G, St-Louis C, Lamothe D, Keller C, Wiper-Bergeron N.
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| Stem Cells 30(12):2619-30. doi: 10.1002/stem.1248.
2012
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| 16 | CEBPB
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| CCAAT/enhancer-binding protein â (C/EBPâ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice.
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| Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, Friedman JE.
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| J Biol Chem 287(41):34349-60. doi: 10.1074/jbc.M112.410613. Epub 2012 Aug 19.
2012
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| 17 | CEBPB, P2RY2
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| P2Y(2) receptor expression is regulated by C/EBP¦Â during inflammation in intestinal epithelial cells.
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| Degagn¨¦ E, Turgeon N, Moore-Gagn¨¦ J, Asselin C, Gendron FP.
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| FEBS J 279(16):2957-65. doi: 10.1111/j.1742-4658.2012.08676.x. Epub 2012 Jul 16.
2012
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| 18 | CEBPB
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| Critical role for CCAAT/enhancer-binding protein â in immune complex-induced acute lung injury.
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| Yan C, Wu M, Cao J, Tang H, Zhu M, Johnson PF, Gao H.
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| J Immunol 189(3):1480-90. doi: 10.4049/jimmunol.1200877. Epub 2012 Jun 25.
2012
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| 19 | CEBPB, EPAS1, MMP13, RUNX2
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| C/EBPB and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2á as the inducer in chondrocytes.
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| Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H.
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| Hum Mol Genet 21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17. 2012
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| 20 | CEBPB, P2RY2
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| P2Y(2) receptor expression is regulated by C/EBPbeta during inflammation in intestinal epithelial cells.
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| Degagné E, Turgeon N, Moore-Gagné J, Asselin C, Gendron FP.
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| FEBS J 279(16):2957-65. doi: 10.1111/j.1742-4658.2012.08676.x. Epub 2012 Jul 16.
2012
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| 21 | CEBPB, KDM4B
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| Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes.
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| Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, Zhu H, Zhang YD, Liu Y, Liu Y, Wang KK, Tang QQ.
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| Cell Death Differ 19(12):1917-27. doi: 10.1038/cdd.2012.75. Epub 2012 Jun 22.
2012
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| 22 | CEBPB, P2RX3, RUNX1
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| Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription.
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| Ugarte GD, Opazo T, Leisewitz F, van Zundert B, Montecino M.
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| J Cell Physiol 227(4):1645-52. doi: 10.1002/jcp.22882.
2012
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| 23 | CEBPA, CEBPB, GATA1, ZFPM1
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| FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
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| Mancini E, Sanjuan-Pla A, Luciani L, Moore S, Grover A, Zay A, Rasmussen KD, Luc S, Bilbao D, O'Carroll D, Jacobsen SE, Nerlov C.
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| EMBO J 31(2):351-65. doi: 10.1038/emboj.2011.390. Epub 2011 Nov 8.
2012
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| 24 | BAZ1A, CEBPB, SMARCA5
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| Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.
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| Steinberg XP, Hepp MI, Fernández García Y, Suganuma T, Swanson SK, Washburn M, Workman JL, Gutiérrez JL.
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| Biochemistry 51(5):952-62. doi: 10.1021/bi201593q. Epub 2012 Jan 23.
2012
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| 25 | CEBPB, FOXA1
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| Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis.
|
| Fujimori K, Amano F.
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| Gene 473(2):150-6. Epub 2010 Dec 15.
2011
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| 26 | CEBPB, PCK2
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| C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
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| Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE.
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| Mol Cell Endocrinol 331(1):102-8. Epub 2010 Aug 24.
2011
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| 27 | CEBPB, TNIP1
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| A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease.
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| Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Häcker H.
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| Proc Natl Acad Sci U S A 108(44):E998-1006. doi: 10.1073/pnas.1106232108. Epub 2011 Oct 19.
2011
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| 28 | CEBPB
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| Role of C/EBPâ transcription factor in adult hippocampal neurogenesis.
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| Cortes-Canteli M, Aguilar-Morante D, Sanz-Sancristobal M, Megias D, Santos A, Perez-Castillo A.
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| PLoS One 6(10):e24842. doi: 10.1371/journal.pone.0024842. Epub 2011 Oct 7.
2011
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| 29 | CEBPB, PDK4
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| Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta).
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| Attia RR, Sharma P, Janssen RC, Friedman JE, Deng X, Lee JS, Elam MB, Cook GA, Park EA.
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| J Biol Chem 286(27):23799-807. doi: 10.1074/jbc.M111.246389. Epub 2011 May 17.
2011
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| 30 | CEBPB, SENP2
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| Control of adipogenesis by the SUMO-specific protease SENP2.
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| Chung SS, Ahn BY, Kim M, Choi HH, Park HS, Kang S, Park SG, Kim YB, Cho YM, Lee HK, Chung CH, Park KS.
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| Mol Cell Biol 30(9):2135-46. Epub 2010 Mar 1.
2010
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| 31 | CEBPB, COL10A1, GADD45B
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| GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.
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| Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB.
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| J Biol Chem 285(11):8395-407. doi: 10.1074/jbc.M109.038638. Epub 2010 Jan 4.
2010
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| 32 | CEBPB, MAPK1, MAPK3
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| MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.
|
| Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.
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| Science 324(5929):938-41.
2009
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| 33 | CEBPB
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| Cyclic regulation of transcription factor C/EBP beta in human endometrium.
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| Plante BJ, Kannan A, Bagchi MK, Yuan L, Young SL.
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| Reprod Biol Endocrinol 7:15. 2009
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| 34 | CEBPA, CEBPB, CEBPE, CEBPG
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| Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors.
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| Cloutier A, Guindi C, Larivée P, Dubois CM, Amrani A, McDonald PP.
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| J Immunol 182(1):563-71.PMID: 19109189 2009
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| 35 | CD1D, CEBPB
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| A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes.
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| Sikder H, Zhao Y, Balato A, Chapoval A, Fishelevich R, Gade P, Singh IS, Kalvakolanu DV, Johnson PF, Gaspari AA.
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| J Immunol 183(3):1657-66. Epub 2009 Jul 10. Erratum in: J Immunol. 2009 Sep 15;183(6):4135.
2009
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| 36 | CEBPB, DAXX
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| Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta.
|
| Wethkamp N, Klempnauer KH.
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| J Biol Chem 284(42):28783-94. Epub 2009 Aug 18.
2009
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| 37 | CEBPB, MAFB
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| Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
|
| Smink JJ, Bégay V, Schoenmaker T, Sterneck E, de Vries TJ, Leutz A.
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| EMBO J 28(12):1769-81. Epub 2009 May 14.
2009
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| 38 | CEBPB, KLF4
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| Transcriptional regulation of adipogenesis by KLF4.
|
| Birsoy K, Chen Z, Friedman J.
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| Cell Metab 7(4):339-47.
2008
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| 39 | CEBPB, DAPK1
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| Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1.
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| Gade P, Roy SK, Li H, Nallar SC, Kalvakolanu DV.
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| Mol Cell Biol 28(8):2528-48. Epub 2008 Feb 4.
2008
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| 40 | CEBPB, EHMT2
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| G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.
|
| Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A.
|
| J Biol Chem 283(39):26357-63. Epub 2008 Jul 21.
2008
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| 41 | CEBPB, CRP, REL
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| The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive protein gene promoter.
|
| Cha-Molstad H, Young DP, Kushner I, Samols D.
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| Mol Immunol 44(11):2933-42. Epub 2007 Feb 28. 2007
|
| 42 | CEBPB, TRIB1
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| Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
|
| Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
|
| J Exp Med 204(9):2233-9. Epub 2007 Aug 27.
2007
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| 43 | CEBPB, TFF1
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| Overexpression of CEBPbeta correlates with decreased TFF1 in gastric cancer.
|
| Sankpal NV, Moskaluk CA, Hampton GM, Powell SM.
|
| Oncogene 25(4):643-9. 2006
|
| 44 | MAPK14, TEAD1, CEBPB
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| TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes.
|
| Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R, Nebreda AR.
|
| Biochem J 396(1):163-72. 2006
|
| 45 | ADIPOQ, CEBPB
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| Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha.
|
| Kita A, Yamasaki H, Kuwahara H, Moriuchi A, Fukushima K, Kobayashi M, Fukushima T, Takahashi R, Abiru N, Uotani S, Kawasaki E, Eguchi K.
|
| Biochem Biophys Res Commun 331(2):484-90. 2005
|
| 46 | DDIT3, CEBPA, CEBPB
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| CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
|
| Pereira RC, Delany AM, Canalis E.
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| Endocrinology 145(4):1952-60. Epub 2003 Dec 18. 2004
|
| 47 | CEBPB, XBP1
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| Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.
|
| Chen C, Dudenhausen EE, Pan YX, Zhong C, Kilberg MS.
|
| J Biol Chem 279(27):27948-56. Epub 2004 Apr 20. 2004
|
| 48 | CEBPB, NOS2
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| A critical role for C/EBPbeta binding to the AABS promoter response element in the human iNOS gene.
|
| Guo Z, Shao L, Feng X, Reid K, Marderstein E, Nakao A, Geller DA.
|
| FASEB J 17(12):1718-20. Epub 2003 Jul 3. 2003
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| 49 | CEBPB, MAP3K1
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| MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.
|
| Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pages G, Pouyssegur J, Kalvakolanu DV.
|
| Proc Natl Acad Sci U S A 99(12):7945-50. 2002
|
| 50 | CEBPB, IL1B
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| Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.
|
| Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK.
|
| J Biol Chem 277(14):11802-10. 2002
|
| 51 | CEBPA, CEBPB
|
| Organization of the promoter region of the human NF-IL6 gene.
|
| Yang Y, Pares-Matos EI, Tesmer VM, Dai C, Ashworth S, Huai J, Bina M.
|
| Biochim Biophys Acta 1577(1):102-8. 2002
|
| 52 | CEBPB, MAPK1, MAPK3
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| ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma.
|
| Hu J, Roy SK, Shapiro PS, Rodig SR, Reddy SP, Platanias LC, Schreiber RD, Kalvakolanu DV.
|
| J Biol Chem 276(1):287-97. 2001
|
| 53 | CEBPA, CEBPB, CEBPD, DIDAN
|
| PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.
|
| Lowell BB.
|
| Cell 99(3):239-42. Review. No abstract available 1999
|
| 54 | CEBPA, CEBPB, STAR
|
| CCAAT/enhancer-binding proteins regulate expression of the human steroidogenic acute regulatory protein (StAR) gene.
|
| Christenson LK, Johnson PF, McAllister JM, Strauss JF 3rd.
|
| J Biol Chem 274(37):26591-8 1999
|
| 55 | CEBPA, CEBPB
|
| CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.
|
| Ossipow V, Descombes P, Schibler U.
|
| Proc Natl Acad Sci U S A 90(17):8219-23. 1993
|
| 56 | IL6RL1, IL6R, CEBPB
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| The interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4.
|
| Szpirer J, et al.
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| Genomics 10 : 539-546. 1991
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| 57 | CEBPB
|
| A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
|
| Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T.
|
| EMBO J 9(6):1897-906. 1990
|