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FLASH GENE

Symbol

PTPRG

contributors: mct/npt/pgu - updated : 05-05-2010

HGNC name	protein tyrosine phosphatase, receptor type, G
HGNC id	9671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p14.2      Physical location : 61.547.242 - 62.280.572
Synonym name	DNA segment,single copy,probe LIB4-84
	protein tyrosine phosphatase gamma
	protein tyrosine phosphatase, receptor type, gamma polypeptide
Synonym symbol(s)	D3S1249, PTPG, RPTPG, H_RG317H01.1, R-PTP-GAMMA, HPTPG
EC.number	3.1.3.48

DNA

TYPE	functioning gene
STRUCTURE	733.33 kb     30 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D3S1401 - D3S1397 - PTPRG - D3S1394 - D3S1400 - D3S1285 - D3S1403 - D3S1404 - D3S1217 - D3S1392 - D3S1395 - D3S1393 - D3S1261 - D3S1398 - D3S1399 - D3S1389 - D3S1296 - D3S1566 - D3S1562 - D3S6 - D3S1405 - qter
Text	see RCA1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002841 30 - 6648 NP_002832 - 1445 - 1993 8382771

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune macrophage Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracellular domain with a stretch of 266 AAs with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), and that may have a function other than catalysis of hydration of metabolic CO2
	carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules
	a carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules

HOMOLOGY

Homologene

FAMILY

protein tyrosine phosphatase (PTP) family

CATEGORY

signaling , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having critical interactions of PTPRG in the extracellular matrix milieu, inducing cell arrest and changes in cell cycle status
	finely regulated protein in dendritic cells and macrophage subsets
	PTPRG, PTPRZ1 and CNTNs are a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with CNTN3, 4, 5, and 6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the majority of high-grade astrocytomas

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC)
Marker
Therapy target

ANIMAL & CELL MODELS