Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LMO2

contributors: mct - updated : 10-09-2016

HGNC name	LIM domain only 2 (rhombotin-like 1)
HGNC id	6642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas           parathyroid       highly Lymphoid/Immune lymph node       highly   tonsils       highly Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, eye, spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domains), for binding to the ubiquitous nuclear adaptor protein LDB1
	a consensus-binding site for a small family of basic leucine zipper proteins containing a proline and acidic amino acid-rich (PAR) domain
	four zinc-finger domains

HOMOLOGY

Homologene

FAMILY

Zinc binding protein family

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	required for yolk sac erythropoiesis
	critical for the regulation of red blood cell development through interactions with TAL1
	acting differently depending on the stage of hematopoietic development
	essential for the regulation of hematopoietic stem cells and formation of erythroid cells
	T-cell oncogenic protein first recognized by gene activation through chromosomal translocations, but it is also responsible for leukaemias arising as secondary (
	key regulator of hematopoietic stem cell development whose ectopic expression in T cells leads to the onset of acute lymphoblastic leukemia
	transcriptional regulator that is essential for normal haematopoietic development
	transcription factor that plays a critical role in both hematopoietic development and vascular remodeling
	is a component of multisubunit DNA-binding transcription factor complexes that regulate gene expression in hematopoietic stem and progenitor cell development
	novel function of LMO2 involving in the regulatory hierarchy of UBA6-USE1-FAT10ylation pathway by targeting the E1 enzyme UBA6

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component	association with LMO1 (and others) for the formation of multimeric DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)
	part of the DNA-binding complex containing LMO2, LDB1, TAL1, and GATA1

INTERACTION

DNA

RNA

small molecule

protein	interacting with BEX2
	also interacting with NHLH2
	modulating the transcriptional activity of HEN1
	interacted strongly to LDB1, which was required for the localization to the nucleus
	probably promotes angiogenesis by up-regulation of FGF2 expression and thereby consequently influences progression of infantile haemangioma
	oncogenic LCK may activate LMO2 promoter through direct interaction
	displayed histone H3K9-me1/2 demethylase activity and induced leukemogenic oncogene LMO2 expression via a synergistic interaction with CREBBP
	TAL1 associates with GATA1, GATA2, lim-only protein LMO2, and LDB1 in a multimeric complex to regulate erythroid transcription
	GATA2 and LMO2 cooperatively regulate VEGFA-induced angiogenesis and lymphangiogenesis via NRP2
	coexpression of full-length, wild-type LDB1 increased LMO2 steady-state abundance, whereas coexpression of mutant proteins deficient in LMO2 binding compromised LMO2 stability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     acute lymphoblastic leukemia (T-ALL) with translocations t(11;14)(p13;q11), t(7;11)(p35;p13) tumoral       loss of function in renal clear cell carcinomas with poor prognosis tumoral fusion       t(14;18)/IGH-BCL2 fusion in diffuse large B-cell lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	promising marker for predicting a better prognosis in pancreatic cancer
Therapy target
	System Type Disorder Pubmed cancer hemopathy   assembly of LMO2 into complexes, via direct LDB1 interaction, is a potential molecular target that could be exploited in LMO2-driven leukemias resistant to existing chemotherapy regimens

ANIMAL & CELL MODELS