| basic FUNCTION
| involved in the inflammatory response |
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stimulating osteoclastogenesis |
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inhibiting EPO gene expression |
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playing a crucial role in the regulation of a number of key cellular processes (potent mediator of bodys response to inflammation, microbial invasion, tissue injury, and immunological response) |
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is a key danger signal released from necrotic cells to trigger CXCL1 secretion and recruitment of neutrophils via IL1R/MYD88 on neighboring mesothelial cells  |
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cell surface IL1A is an essential cell-autonomous regulator of the senescence-associated IL6/IL8 cytokine network |
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intracellular IL1A is a chromatin-associated cytokine and highly dynamic in the nucleus of living cells |
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in apoptotic cells, is retained within the chromatin fraction and is not released along with the cytoplasmic contents |
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platelets are a key source of IL1A and platelet activation of brain endothelium via IL1A is likely a critical step for the entry of white blood cells, major contributors to inflammation-mediated injury in the brain |
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is a critical regulator of blood-testis barrier (BTB) dynamics |
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IL1A, released from dying cells, initiates sterile inflammation by inducing recruitment of neutrophils |
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IL1B, IL1A both bind to the same IL1 receptor (IL1R1) and are potent proinflammatory cytokines |
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may have a critical function in the development of obesity |
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autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL1A, IL1B and its consequential effects on IL23A secretion |
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IL1A and IL23A signaling seems to be closely regulated through MYD88 in both innate and adaptive immune cells |
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in macrophages IL1A primarily acts as an alarmin that is rapidly released upon cell damage to activate early mechanisms of host defense |
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is a key senescence-associated (SA) proinflammatory cytokine that acts as a critical upstream regulator of the senescence-associated (SA) secretory phenotype (SASP) |
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IL1A and IL1B, are central to host responses to infection and to damaging sterile inflammation |
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IL1A, IL1B are important participants in the age-related exhaustion of ovarian reserve in mammalian, possibly by enhancing the expression of inflammatory genes and promoting apoptotic pathways |
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IL1A and IL1B are key players in the innate immune system |
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triggers lung responses requiring macrophage proliferation and maturation from tissue-resident macrophages |
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is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction |
